Besser, Lilah M.; Lovasi, Gina S.; Michael, Yvonne L.; Garg, Parveen; Hirsch, Jana A.; Siscovick, David; Hurvitz, Phil; Biggs, Mary L.; Galvin, James E.; Bartz, Traci M.; Longstreth, W. T. (2021). Associations between Neighborhood Greenspace and Brain Imaging Measures in Non-Demented Older Adults: The Cardiovascular Health Study. Social Psychiatry And Psychiatric Epidemiology, 56(9), 1575 – 1585.
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Abstract
Purpose Greater neighborhood greenspace has been associated with brain health, including better cognition and lower odds of Alzheimer's disease in older adults. We investigated associations between neighborhood greenspace and brain-based magnetic resonance imaging (MRI) measures and potential effect modification by sex or apolipoprotein E genotype (APOE), a risk factor for Alzheimer's disease. Methods We obtained a sample of non-demented participants 65 years or older (n = 1125) from the longitudinal, population-based Cardiovascular Health Study (CHS). Greenspace data were derived from the National Land Cover Dataset. Adjusted multivariable linear regression estimated associations between neighborhood greenspace five years prior to the MRI and left and right hippocampal volume and 10-point grades of ventricular size and burden of white matter hyperintensity. Interaction terms tested effect modification by APOE genotype and sex. CHS data (1989-1999) were obtained/analyzed in 2020. Results Participants were on average 79 years old [standard deviation (SD) = 4], 58% were female, and 11% were non-white race. Mean neighborhood greenspace was 38% (SD = 28%). Greater proportion of greenspace in the neighborhood five years before MRI was borderline associated with lower ventricle grade (estimate: - 0.30; 95% confidence interval: - 0.61, 0.00). We observed no associations between greenspace and the other MRI outcome measures and no evidence of effect modification by APOE genotype and sex. Conclusion This study suggests a possible association between greater greenspace and less ventricular enlargement, a measure reflecting global brain atrophy. If confirmed in other longitudinal cohort studies, interventions and policies to improve community greenspaces may help to maintain brain health in older age.
Keywords
Mild Cognitive Impairment; Ventricular Enlargement; Residential Greenness; Hippocampal Atrophy; Volume; Disease; Environment; Progression; Symptoms; Dementia; Neighborhood; Green Space; Mri; Brain Volume; Hippocampal; White Matter
The Urban Design & Planning Interdisciplinary Ph.D. at the University of Washington is one of 39 Ph.D. programs in urban and regional planning in North America, and one of the oldest, founded in 1967.
This program brings together faculty from disciplines ranging from Architecture to Sociology to focus on the interdisciplinary study of urban problems and interventions. Covering scales from neighborhoods to metropolitan areas, the program addresses interrelationships between the physical environment, the built environment, and the social, economic, and political institutions and processes that shape urban areas. The breadth of this program permits students to pursue doctoral studies in the various aspects of urban design and planning as well as in a number of related social science, natural resource, and engineering areas.
The Program seeks to prepare scholars who can advance the state of research, practice, and education related to the built environment and its relationship to society and nature in metropolitan regions throughout the world. The program provides a strong interdisciplinary educational experience that draws on the resources of the entire University, and on the laboratory provided by the Seattle metropolitan region and the Pacific Northwest. The program emphasizes the educational values of interdisciplinarity, intellectual leadership and integrity, and the social values of equity, democracy and sustainability. It seeks to promote deeper understanding of the ways in which public decisions shape and are shaped by the urban physical, social, economic, and natural environment. The program envisions its graduates becoming leaders in the international community of researchers, practitioners and educators who focus on improving the quality of life and environment in metropolitan regions.
The Urban Form Lab (UFL) research aims to affect policy and to support approaches to the design and planning of more livable environments. The UFL specializes in geospatial analyses of the built environment using multiple micro-scale data in Geographic Information Systems (GIS). Current research includes the development of novel GIS routines for performing spatial inventories and analyses of the built environment, and of spatially explicit sampling techniques. Projects address such topics as land monitoring, neighborhood and street design, active transportation, non-motorized transportation safety, physical activity, and access to food environments.
Research at the UFL has been supported by the U.S. and Washington State Departments of Transportation, the Centers for Disease Control and Prevention, the Robert Wood Johnson Foundation, the National Institutes of Health, and local agencies.
The Urban Form Lab is directed by Anne Vernez Moudon, Dr es Sc, a leading researcher and educator in quantifying the properties of the built environment as related to health and transportation behaviors. Philip M. Hurvitz, PhD, a veteran of geographic information science and data processing, leads data management and GIS work.
Phil Hurvitz is a research scientist with a primary appointment in the UW Center for Studies in Demography and Ecology, and is an Affiliate Associate Professor in Urban Design & Planning in the University of Washington College of Built Environments Urban Form Lab. He received his PhD in 2010, and has been on the faculty since 2012. He specializes in the objective measurement and analysis of the built environment using GIScience methodology. His current research investigates the relationship between health-related behaviors and built environment at fine spatial and temporal scales. Using new-generation devices that measure activity and location in real time, the data are being used to find associations between the types of activities people engage in and the types of environments people use as they go about their daily lives. He collaborates with researchers specializing in nutritional epidemiology, exercise physiology, rehabilitation medicine, and psychology for the purpose of understanding the relationships between built environment, diet, and physical activity. Phil received a Master of Forest Resources degree in 1994 at the UW College of Forest Resources where he helped develop and implement a GIS for the Makah Indian Nation. His Bachelor’s degree (1983) is from Seattle University in Humanities. Prior to his current appointment, he worked as a GIS specialist for the College of Forest Resources, the City of SeaTac, the Seattle Water Department, and an instructor at the University of Washington and Green River Community College.