August 10, 2022
Deciphering the Impact of Urban Built Environment Density on Respiratory Health Using a Quasi-cohort Analysis of 5495 Non-smoking Lung Cancer Cases
Wang, Lan; Sun, Wenyao; Moudon, Anne Vernez; Zhu, Yong-guan; Wang, Jinfeng; Bao, Pingping; Zhao, Xiaojing; Yang, Xiaoming; Jia, Yinghui; Zhang, Surong; Wu, Shuang; Cai, Yuxi. (2022). Deciphering the Impact of Urban Built Environment Density on Respiratory Health Using a Quasi-cohort Analysis of 5495 Non-smoking Lung Cancer Cases. Science Of The Total Environment, 850.
Abstract
Introduction: Lung cancer is a major health concern and is influenced by air pollution, which can be affected by the den-sity of urban built environment. The spatiotemporal impact of urban density on lung cancer incidence remains unclear, especially at the sub-city level. We aimed to determine cumulative effect of community-level density attributes of the built environment on lung cancer incidence in high-density urban areas. Methods: We selected 78 communities in the central city of Shanghai, China as the study site; communities included in the analysis had an averaged population density of 313 residents per hectare. Using data from the city cancer surveil-lance system, an age-period-cohort analysis of lung cancer incidence was performed over a five-year period (2009-2013), with a total of 5495 non-smoking/non-secondhand smoking exposure lung cancer cases. Community -level density measures included the density of road network, facilities, buildings, green spaces, and land use mixture. Results: In multivariate models, built environment density and the exposure time duration had an interactive effect on lung cancer incidence. Lung cancer incidence of birth cohorts was associated with road density and building coverage across communities, with a relative risk of 1middot142 (95 % CI: 1middot056-1middot234, P = 0middot001) and 1middot090 (95 % CI: 1middot053-1middot128, P < 0middot001) at the baseline year (2009), respectively. The relative risk increased exponentially with the exposure timeduration. As for the change in lung cancer incidence over the five-year period, lung cancer incidence of birth cohorts tended to increase faster in communities with a higher road density and building coverage. Conclusion: Urban planning policies that improve road network design and building layout could be important strate-gies to reduce lung cancer incidence in high-density urban areas.
Keywords
Air-quality; Pollutant Dispersion; Risk-factors; Land-use; Mortality; Exposure; Cities; Transport; Compact City; Longitudinal Analysis; Lung Cancer; Urban Planning
